An association between knee OA and the severity of AS was also suggested byĮkim et al. 27 also reported a significant relationship between severe coronary stenosis and 25, 26 showed a significant relationship between femoral plaques,Ĭarotid intima-media thickness, and hand OA. Recent studies have shown that cardiovascular disease and OA also have a clinical relationship. While there appears to be a relationship between cholesterol and OA, theĮffectiveness of statin treatment in OA has not been fully determined. Have been investigated, but the results are conflicting. The effects of statins on progression of knee or hip OA 7 Taken together, these results emphasize the importance of cholesterol in That were fed a high-cholesterol diet compared with controls. 21 Degradative OA symptoms were reported in rats with destabilized knees Hypercholesterolemia on progression of OA. A further study in ApoE knockout mice showed the effects of Showed that synovial activation was significantly increased in response to high 20 This study demonstrated that synovial production of pro-inflammatoryĬytokines was increased in mice with high LDL levels. 19 Another study showed that elevated LDL levels induced OA-like changes inĪn inflammatory OA model in mice with a cholesterol-rich diet or LDL receptor deficiency. Inflammation and accelerated ectopic bone spur formation during experimental OA 18Ī recent study that used ApoE knockout mice showed that increased synovial
#The lox apparel free#
Triglycerides, APO, and free cholesterol. Molecules with cholesterol esters in a hydrophilic shell of phospholipids, LDL is a major group of lipoproteins that transport Serum levels of low-density lipoprotein (LDL) are elevated in
Possible involvement of cholesterol in the pathogenesis of OA Highlight the relationship between dyslipidemia and OA. Predictors of intervertebral disc degradation in a Chinese population. These authors also suggested that serum lipid levels could be useful 17 suggested that dyslipidemia is associated with a higher risk of lumbar disc 16 demonstrated that patients with OA have the highest concentrations ofĪpolipoprotein (APO) A-I and total cholesterol compared with controls. 14 Furthermore, a cohort study showed a correlation between high serumĬholesterol levels and generalized OA. 13 A case–control study suggested that serum cholesterol was an independent Representative disease of dyslipidemia, is a risk factor of knee and handĬross-sectional study also showed a correlation between hypercholesterolemia and In this narrative review, weĪddress the evidence underlying the molecular mechanisms of hyperlipidemia and AS inĮpidemiology of the association of dyslipidemia and OAĮpidemiological studies have shown that hypercholesterolemia, which is a Mechanisms underlying AS and OA are currently underway. Investigations to clarify the factors and
7 – 9 Hypercholesterolemia, whichĬauses atherosclerosis (AS), has been reported to be associated with the risk of Pathogenesis of degeneration of articular cartilage. 6 Some studies have also suggested involvement of lipid peroxidation in the Metabolic syndrome (MetS) disorders are involved in the pathogenesis and progression Interestingly, recent studies have shown that 5 Therefore, the cause of OA was believed to be mainly wear and tear ofĬhondrocytes by mechanical stress. OA was originally considered to be caused by mechanical stress due to obesity. Currently, clarifying the cause of OA and developing fundamental Until recently, conservative and curative treatments for OA have not beenĭetermined. The medical costs of arthroplasty have been increasing
2 Generally, treatment of end-stage OA requires surgery, such as total kneeĪrthroplasty. 1 The number of patients with knee OA in Japan is estimated to be approximatelyĢ5 million (ROAD study). Osteoarthritis (OA) is a major and common disease with a prevalence that isĬontinuously increasing because of global aging. Of OA and to reveal common underlying molecular pathways that are shared by MetS The purpose of this narrative review is to summarize theĬurrent understanding of the role of the LOX-1/ox-LDL system in the pathogenesis That ox-LDL and low-density lipoprotein receptor 1 (LOX-1) are involved in the Play a role in the pathogenesis of atherosclerosis. Oxidation of low-density lipoprotein (ox-LDL) is believed to Underlying similar molecular mechanisms because the prevalence of both diseases Researchers believe that OA and atherosclerosis have MetS disorders are common diseases that also Hyperlipidemia, diabetes mellitus, and obesity, may be involved in the Suggested that metabolic syndrome (MetS) disorders, such as hypertension, Aging, obesity,Īnd sex are considered the main risk factors of OA. Osteoarthritis (OA) is a chronic joint disorder that causes degeneration ofĬartilage, synovial inflammation, and formation of osteophytes.
0 kommentar(er)
